Simulation of blood flow using particle-based methods: From single cell dynamics to collective behavior

  • Event Date: 2022-06-16
  • Complex Systems
  • Speaker: Chien Wei (Italian Institute of Technology)  /  Host:
    Place: Chee-Chun Leung Cosmology Hall 4F, NTU & Online (Webex)

Time:2022/06/16 (Thur.) 14:00
Place:Chee-Chun Leung Cosmology Hall 4F, NTU & Online (Webex)


Meeting number:2561 471 6694
Password:aJRK7pUPJ87 (25757787 from phones and video systems)

Modeling blood with cellular details can help to understand single cell dynamics in microfluidics and the complex rheology of blood cell suspension flow. In this talk, I will briefly introduce the coarse-grained red blood cell (RBC) model immersed in Newtonian fluid modeled by smoothed-dissipated-particle dynamics method (SDPD).1 This model has been calibrated mechanically and shows consistent dynamic states in simple shear flow with experiments. We would focus on two specific intrinsic properties of a single RBC: the deformability of the membrane, and the viscosity ratios between the cytoplasm and the suspended medium. I will demonstrate promising strategies to exploit deformability-based separation for RBC by triggering the transition of the dynamic states in a more sophisticated microfluidics device: DLD (Deterministic lateral displacement). 2 Furthermore, I will also demonstrate how the viscosity contrasts can scale up and affect the structure of the suspension flow. 3
[1] Dmitry A. Fedosov, Hiroshi Noguchi, and Gerhard Gompper, Biomech Model Mechanobiol (2014) 13:239–258
[2] W. Chien, Z. Zhang, G. Gompper and D. A. Fedosov, Biomicrofluidics 13 (4), 044106 (2019).
[3] W. Chien, G. Gompper, and D. A. Fedosov, Microcirculation, micc.12668 (2020).