Simulation of blood flow using particle-based methods: From single cell dynamics to collective behavior
Time：2022/06/16 (Thur.) 14:00
Place：Chee-Chun Leung Cosmology Hall 4F, NTU & Online (Webex)
Modeling blood with cellular details can help to understand single cell dynamics in microfluidics and the complex rheology of blood cell suspension flow. In this talk, I will briefly introduce the coarse-grained red blood cell (RBC) model immersed in Newtonian fluid modeled by smoothed-dissipated-particle dynamics method (SDPD).1 This model has been calibrated mechanically and shows consistent dynamic states in simple shear flow with experiments. We would focus on two specific intrinsic properties of a single RBC: the deformability of the membrane, and the viscosity ratios between the cytoplasm and the suspended medium. I will demonstrate promising strategies to exploit deformability-based separation for RBC by triggering the transition of the dynamic states in a more sophisticated microfluidics device: DLD (Deterministic lateral displacement). 2 Furthermore, I will also demonstrate how the viscosity contrasts can scale up and affect the structure of the suspension flow. 3
 Dmitry A. Fedosov, Hiroshi Noguchi, and Gerhard Gompper, Biomech Model Mechanobiol (2014) 13:239–258
 W. Chien, Z. Zhang, G. Gompper and D. A. Fedosov, Biomicrofluidics 13 (4), 044106 (2019).
 W. Chien, G. Gompper, and D. A. Fedosov, Microcirculation, micc.12668 (2020).